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Clin Calcium. 2006 Jul;16(7):1213-19.

[Matrix gene regulation in cartilage].

[Article in Japanese]

Author information

1
Kyushu University, Graduate School of Medical Sciences, Department of Orthopaedic Surgery.

Abstract

Regulation of Col2a1 is a key event in the cartilage development. Many factors including cell adhesion, hypoxia, growth factors or cytokines regulate various transcription factors or co-factors which influence the expression of Col2a1. Sox9 is a key transcriptional activator that is involved in most of these events by cooperating or interfering with these factors. The balance of positive and negative regulators determines the level of matrix gene expression.

PMID:
16816484
DOI:
CliCa060712131219
[Indexed for MEDLINE]
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