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Genetics. 2006 Sep;174(1):519-23. Epub 2006 Jul 2.

Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements.

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1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853-2703, USA.

Abstract

We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for approximately 160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected despite dramatic decreases in spore viability, suggesting that frameshift and/or other unrepaired DNA replication lesions play a greater role than chromosomal instability in decreasing viability in MMR-defective strains.

PMID:
16816424
PMCID:
PMC1569777
DOI:
10.1534/genetics.106.059311
[Indexed for MEDLINE]
Free PMC Article
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