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J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1.

Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

Author information

1
Department of Medical Microbiology, Old Medical School, Leeds General Infirmary Great George Street, Leeds LS1 2EX, UK.

Abstract

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.

PMID:
16816396
DOI:
10.1093/jac/dkl224
[Indexed for MEDLINE]

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