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Am J Geriatr Psychiatry. 2006 Jul;14(7):625-8.

Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study.

Author information

1
Department of Neuropsychiatry and Clinical Research Institute, Seoul National University, Seoul, Korea.

Abstract

OBJECTIVE:

This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD).

METHOD:

Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method.

RESULTS:

The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group.

CONCLUSIONS:

These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.

[Indexed for MEDLINE]

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