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Trends Biotechnol. 2006 Aug;24(8):339-42. Epub 2006 Jul 11.

Engineered chloroplasts as vaccine factories to combat bioterrorism.

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  • 1Applied Biotechnology Institute, 101 Gateway Boulevard, Suite 100, College Station, TX 77845, USA. sstreatfield@fraunhofer-cmb.org

Abstract

Bacillus anthracis is ideal for making biological weapons, but the licensed anthrax vaccine is unsuitable for widespread public administration. Recombinant subunit-vaccine candidates offer potential alternatives, and plant-based production systems facilitate the inexpensive bulking of target antigens. A recent report demonstrates expression of anthrax protective antigen in tobacco chloroplasts--this material is immunogenic and protective when injected into mice. Provided an economic purification scheme can be developed, this technology holds promise for an improved vaccine.

PMID:
16815579
DOI:
10.1016/j.tibtech.2006.06.006
[PubMed - indexed for MEDLINE]
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