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Biochim Biophys Acta. 2006 May;1759(5):234-9. Epub 2006 May 22.

Characterization of the MCT-1 pseudogene: identification and implication of its location in a highly amplified region of chromosome 20.

Author information

1
University of Maryland Greenebaum Cancer Center, Department of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA. sunandi@som.umaryland.edu

Abstract

The MCT-1 oncogene was initially identified as an amplified gene on chromosome Xq22-24 in a T-cell lymphoma. MCT-1 is over-expressed in a subset of diffuse large B-cell lymphoma (DLBCL), a common form of Non-Hodgkin's Lymphoma (NHL). We have identified a pseudogene for MCT-1 (PsiMCT-1) that is located on chromosome 20q11.2, a region within an amplicon containing several important genes frequently amplified in certain breast and ovarian cancers. Genomic analysis revealed that PsiMCT-1 is a processed pseudogene. Interestingly, both MCT-1 and its pseudogene are located on regions of the genome that are frequently amplified in several different human malignancies. MCT-1 is the oldest known oncogene and its insertion as a pseudogene occurred at a later time point in evolution. Existence of PsiMCT-1 should be considered when analyzing genomic amplification and or expression of MCT-1. Analysis of MCT-1 and PsiMCT-1 might provide clues to cancer genes and their evolution across species.

PMID:
16815567
DOI:
10.1016/j.bbaexp.2006.05.003
[Indexed for MEDLINE]

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