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Antiviral Res. 2006 Sep;71(2-3):372-8. Epub 2006 Jun 9.

Antivirals for influenza: historical perspectives and lessons learned.

Author information

1
University of Virginia, School of Medicine, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA. fgh@virginia.edu

Abstract

The development of the currently available classes of antivirals, the M2 proton channel inhibitors and the neuraminidase inhibitors, provides valuable perspectives relevant to the field of antiviral chemotherapy in general and insights into aspects of viral pathogenesis and antiviral resistance relevant specifically to influenza. The efficacy observed with these antiviral drugs has proven the importance of these antiviral targets, as well as the principle that chemoprophylaxis and early treatment are possible in influenza infections with small molecular weight inhibitors.

PMID:
16815563
DOI:
10.1016/j.antiviral.2006.05.016
[Indexed for MEDLINE]

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