Format

Send to

Choose Destination
Lancet. 2006 Jul 1;368(9529):83-6.

Are statins analogues of vitamin D?

Author information

1
Blackburn Royal Infirmary, Blackburn, Lancashire BB6 8HE, UK. Susan.Rogers@elht.nhs.uk

Abstract

There are many reasons why the dietary-heart-cholesterol hypothesis should be questioned, and why statins might be acting in some other way to reduce the risk of coronary heart disease. Here, I propose that rather than being cholesterol-lowering drugs per se, statins act as vitamin D analogues, and explain why. This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. It seems likely that statins activate vitamin D receptors.

PMID:
16815382
DOI:
10.1016/S0140-6736(06)68971-X
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center