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Neuron. 2006 Jul 6;51(1):1-3.

Neurotrophins and dementia--keeping in touch.

Author information

1
Sigrid Jusélius Laboratory of Molecular Neuroscience, Neuroscience Center, University of Helsinki, 00014, Helsinki, Finland.

Abstract

Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain. Two papers in this issue of Neuron show that reduced retrograde transport or signaling of the neurotrophins NGF or BDNF, respectively, may account for the neuronal pathology in mouse models of Down's syndrome.

PMID:
16815323
DOI:
10.1016/j.neuron.2006.06.019
[Indexed for MEDLINE]
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