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Fertil Steril. 2006 Sep;86(3):588-96. Epub 2006 Jun 30.

Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization-embryo transfer.

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1
Department of Gynecology-Obstetrics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14222, USA.

Abstract

OBJECTIVE:

To study the value of E(2) production during controlled ovarian hyperstimulation (COH) in predicting IVF-ET outcome.

DESIGN:

Historical cohort.

SETTING:

Academic infertility center.

PATIENT(S):

A cohort of 270 patients who completed 324 consecutive IVF-ET treatment cycles.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Area under the curve for E(2) levels (AUC-E(2)) from the first day of COH until the day of hCG administration was calculated and cycles grouped into low, average, and high AUC-E(2) groups. Clinical pregnancy rates per cycle were compared among the three groups, and correlations with AUC-E(2) values were calculated for all patients and after sub-grouping according to age, COH protocol and infertility diagnosis.

RESULT(S):

Cycles with low and high AUC-E(2) values had significantly lower pregnancy rates particularly in patients 35 years or older. There was a positive correlation between AUC-E(2) and pregnancy rates up to a certain AUC-E(2) level above which a negative correlation was found. The turning point between positive and negative correlations occurred at a significantly lower AUC-E(2) level in patients 35 years or older.

CONCLUSIONS:

Estradiol production during COH correlates with IVF-ET outcome. Women >35 years of age seem more vulnerable to high E(2) levels.

[Indexed for MEDLINE]

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