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Science. 2006 Jun 30;312(5782):1946-9.

Lhx2 maintains stem cell character in hair follicles.

Author information

1
Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021.

Abstract

During embryogenesis, stem cells are set aside to fuel the postnatal hair cycle and repair the epidermis after injury. To define how hair follicle stem cells are specified and maintained in an undifferentiated state, we developed a strategy to isolate and transcriptionally profile embryonic hair progenitors in mice. We identified Lhx2 as a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors.

PMID:
16809539
PMCID:
PMC2405918
DOI:
10.1126/science.1128004
[Indexed for MEDLINE]
Free PMC Article

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