Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2006 Aug 4;313(5787):640-4. Epub 2006 Jun 29.

Netrins promote developmental and therapeutic angiogenesis.

Author information

1
Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA.

Abstract

Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.

PMID:
16809490
PMCID:
PMC2577078
DOI:
10.1126/science.1124704
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center