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Brain Inj. 2006 Jun;20(7):759-65.

Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury.

Author information

1
Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, New York 14472, USA. jeff_barzarian@urmc.rochester.edu

Abstract

PRIMARY OBJECTIVE:

To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI).

RESEARCH DESIGN:

A prospective study of 35 mild TBI subjects presenting to the emergency department.

METHODS AND PROCEDURES:

Six hour serum S-100B and C-tau levels compared to 3-month Rivermead Post Concussion Questionnaire (RPCQ) scores and post-concussive syndrome (PCS).

MAIN OUTCOMES AND RESULTS:

The linear correlation between marker levels and RPCQ scores was weak (S-100B: r = 0.071, C-tau: r = -0.21). There was no statistically significant correlation between marker levels and 3-month PCS (S-100B: AUC = 0.589, 95%CI. 038, 0.80; C-tau: AUC = 0.634, 95%CI 0.43, 0.84). The sensitivity of these markers ranged from 43.8-56.3% and the specificity from 35.7-71.4%.

CONCLUSIONS:

Initial serum S-100B and C-tau levels appear to be poor predictors of 3-month outcome after mild TBI.

PMID:
16809208
DOI:
10.1080/02699050500488207
[Indexed for MEDLINE]

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