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Bioorg Med Chem Lett. 2006 Sep 1;16(17):4543-7. Epub 2006 Jun 30.

Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.

Author information

1
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. thavalakulamgar.sasikumar@spcorp.com

Abstract

Acylated and aroylated hydrazinoclozapines are highly potent dopamine D(1) antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D(1)K(i) of 1.6 nM and 212-fold selectivity over D(2) receptor.

PMID:
16809034
DOI:
10.1016/j.bmcl.2006.06.022
[Indexed for MEDLINE]

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