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Nutr Rev. 2006 Jun;64(6):295-9.

How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol.

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Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA.


alpha-Tocopherol is the only form of vitamin E in vitamin supplements, whereas gamma-tocopherol is the predominant form of vitamin E in the US diet. gamma-Tocopherol has beneficial properties as an anti-inflammatory and possibly anti-atherogenic and anticancer agent. Excess a-tocopherol taken in supplements causes a reduction of gamma-tocopherol concentration in plasma. The biochemical mechanism of this effect, which is important to human nutrition, has recently been elucidated.

[Indexed for MEDLINE]

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