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FEBS Lett. 1991 Sep 23;290(1-2):157-8.

Heterogeneity in human soluble guanylate cyclase due to alternative splicing.

Author information

1
Department of Pharmacology, Umeå University, Sweden.

Abstract

Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.

PMID:
1680753
DOI:
10.1016/0014-5793(91)81248-7
[Indexed for MEDLINE]
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