Format

Send to

Choose Destination
Eur J Pain. 2007 May;11(4):406-14. Epub 2006 Jun 27.

Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain.

Author information

1
Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA 94143-0440, USA. Brian.Schmidt@ucsf.edu

Abstract

In this study we investigated the role of endothelin-1 (ET-1) and its peripheral receptor (ET-A) in carcinoma-induced pain in a mouse cancer pain model. Tumors were induced in the hind paw of female mice by local injection of cells derived from a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at four days after SCC inoculation and lasted to 28 days, the last day of measurement. Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect. These findings support the suggestion that ET-1 and ET-A receptors contribute to the severity of carcinoma-induced soft tissue cancer pain.

PMID:
16807013
DOI:
10.1016/j.ejpain.2006.05.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center