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Bioorg Med Chem Lett. 2006 Sep 1;16(17):4548-53. Epub 2006 Jun 27.

Modification of the clozapine structure by parallel synthesis.

Author information

1
Department of Chemical Research, Schering-Plough Research Institute K15 2545, Kenilworth, NJ 07033, USA. jing.su@spcorp.com

Abstract

A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D(1)-selective and D(2)-selective compounds can be obtained.

PMID:
16806922
DOI:
10.1016/j.bmcl.2006.06.034
[Indexed for MEDLINE]

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