Format

Send to

Choose Destination
Curr Opin Cell Biol. 2006 Aug;18(4):358-64. Epub 2006 Jun 27.

Endoplasmic reticulum architecture: structures in flux.

Author information

1
National Research Council Institute for Neuroscience and Department of Medical Pharmacology, University of Milan, via Vanvitelli 32, 20129 Milano, Italy. n.borgese@in.cnr.it

Abstract

The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.

PMID:
16806883
PMCID:
PMC4264046
DOI:
10.1016/j.ceb.2006.06.008
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center