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Curr Opin Cell Biol. 2006 Aug;18(4):358-64. Epub 2006 Jun 27.

Endoplasmic reticulum architecture: structures in flux.

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National Research Council Institute for Neuroscience and Department of Medical Pharmacology, University of Milan, via Vanvitelli 32, 20129 Milano, Italy.


The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.

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