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Biol Psychiatry. 2006 Nov 15;60(10):1147-54. Epub 2006 Jun 27.

Acute stress reduces reward responsiveness: implications for depression.

Author information

1
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA.

Abstract

BACKGROUND:

Stress, one of the strongest risk factors for depression, has been linked to "anhedonic" behavior and dysfunctional reward-related neural circuitry in preclinical models.

METHODS:

To test if acute stress reduces reward responsiveness (i.e., the ability to modulate behavior as a function of past reward), a signal-detection task coupled with a differential reinforcement schedule was utilized. Eighty female participants completed the task under both a stress condition, either threat-of-shock (n = 38) or negative performance feedback (n = 42), and a no-stress condition.

RESULTS:

Stress increased negative affect and anxiety. As hypothesized based on preclinical findings, stress, particularly the threat-of-shock condition, impaired reward responsiveness. Regression analyses indicate that self-report measures of anhedonia predicted stress-induced hedonic deficits even after controlling for anxiety symptoms.

CONCLUSIONS:

These findings indicate that acute stress reduces reward responsiveness, particularly in individuals with anhedonic symptoms. Stress-induced hedonic deficit is a promising candidate mechanism linking stressful experiences to depression.

PMID:
16806107
PMCID:
PMC2288705
DOI:
10.1016/j.biopsych.2006.03.037
[Indexed for MEDLINE]
Free PMC Article
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