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J Neurochem. 2006 Jun;97(6):1520-33.

Common molecular mechanisms in explicit and implicit memory.

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Instituto de Neurociencias de Alicante (UMH-CSIC), Campus de Sant Joan, Spain.


Cellular and molecular studies of both implicit and explicit memory suggest that experience-dependent modulation of synaptic strength and structure is a fundamental mechanism by which these memories are encoded and stored within the brain. In this review, we focus on recent advances in our understanding of two types of memory storage: (i) sensitization in Aplysia, a simple form of implicit memory, and (ii) formation of explicit spatial memories in the mouse hippocampus. These two processes share common molecular mechanisms that have been highly conserved through evolution.

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