Send to

Choose Destination
Annu Rev Genet. 2006;40:187-208.

Cellular responses to DNA damage: one signal, multiple choices.

Author information

Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA.


DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center