Format

Send to

Choose Destination
Cancer Lett. 1991 Oct;60(1):85-92.

Transglutaminase activity in human colorectal carcinomas of differing metastatic potential.

Author information

1
Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103-2425.

Abstract

Transglutaminase (TGA) activity in four human colorectal carcinoma cell lines of differing metastatic potential, and the effects of mild proteolysis on this activity, was investigated. Rank order of metastatic activity measured in nude mice (intrasplenic injection) was found to be LS174T greater than SW620 greater than WiDr greater than SW480. Rank orders of TGA activity were SW480 greater than WiDr greater than SW620 greater than LS174T. Proteolysis of cell lysates increased LS174T TGA activity 42-fold, SW620 2-fold without affecting WiDr or SW480 activity. Hence a negative association exists between metastatic potential and TGA activity in human colorectal carcinoma cells. Furthermore, a positive association exists between proteolytic activation of TGA and metastatic potential.

PMID:
1680545
DOI:
10.1016/0304-3835(91)90052-j
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center