Format

Send to

Choose Destination
JAMA. 2006 Jun 28;295(24):2874-81.

Depression and cardiovascular disease: healing the broken-hearted.

Author information

1
Veterans Affairs Medical Center and University of California, San Francisco Medical Center, San Francisco, CA 94121, USA. mary.whooley@ucsf.edu

Abstract

Major depressive disorder is a risk factor for the development of incident coronary heart disease events in healthy patients and for adverse cardiovascular outcomes in patients with established heart disease. Depression is present in 1 of 5 outpatients with coronary heart disease and in 1 of 3 outpatients with congestive heart failure, yet the majority of cases are not recognized or appropriately treated. It is not known whether treating depression improves cardiovascular outcomes, but antidepressant treatment with selective serotonin reuptake inhibitors is generally safe, alleviates depression, and improves quality of life. This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder.

PMID:
16804154
PMCID:
PMC2771193
DOI:
10.1001/jama.295.24.2874
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center