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Ann Neurol. 2006 Jul;60(1):145-7.

Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.

Author information

1
Institute of Neurology, Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

PMID:
16802294
DOI:
10.1002/ana.20889
[Indexed for MEDLINE]

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