Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2006 Jul;50(7):2553-6.

Risk factors for selection of the L74I reverse transcriptase mutation in human immunodeficiency virus type 1-infected patients.

Author information

1
Department of Virology, Pitié-Salpêtrière Hospital, 75013 Paris, France. marc.wirden@psl.aphp.fr

Abstract

We analyzed 3,475 human immunodeficiency virus sequences and 241 therapeutic histories. The L74I mutation was carried by 7% of viruses. L74I was strongly associated with T215F, K70R, and V75M/S/T/A mutations and increased with the number of thymidine analog mutations. It seemed to be linked to the use of abacavir or efavirenz.

PMID:
16801444
PMCID:
PMC1489786
DOI:
10.1128/AAC.00092-06
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center