Format

Send to

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2006 Jul;50(7):2530-2.

Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.

Author information

1
Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, NJ 08869, USA. tdavies@prdus.jnj.com

Abstract

The activities of ceftobiprole and other beta-lactams were examined with 30 Streptococcus pneumoniae isolates containing multiple pbp1a, pbp2b, and pbp2x mutations. The highest ceftobiprole MIC was 1 microg/ml, while the comparator MICs were 16 to 64 microg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 microg/ml (ceftobiprole) and 4 microg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.

PMID:
16801437
PMCID:
PMC1489808
DOI:
10.1128/AAC.00238-06
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center