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Proc Am Thorac Soc. 2006 Jul;3(5):405-8.

Progress in chronic obstructive pulmonary disease genetics.

Author information

  • 1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ed.silverman@channing.harvard.edu

Abstract

Familial aggregation of chronic obstructive pulmonary disease (COPD) has been demonstrated, suggesting that genetic factors likely influence the variable development of chronic airflow obstruction in response to smoking. A variety of approaches have been used to identify novel COPD susceptibility genes, including association studies, linkage analysis, and rare variant analysis. Future directions for COPD research include genomewide association studies and animal model genetic studies.

PMID:
16799082
PMCID:
PMC2658703
DOI:
10.1513/pats.200603-092AW
[PubMed - indexed for MEDLINE]
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