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Ann Thorac Surg. 2006 Jul;82(1):338-40.

Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazole.

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Division of Thoracic Surgery, and Department of Surgery, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.


We describe a 57-year-old woman with acute lymphoblastic leukemia who had a cavitary lesion develop in the right upper lobe caused by Cunninghamella bertholletiae, a zygomycete. The infection was resistant to both high-dose liposomal amphotericin B and voriconazole. The current report demonstrates successful treatment, even in the setting of subsequent bone marrow transplantation and immunosuppression, using a combination of surgical resection and posaconazole therapy.

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