Format

Send to

Choose Destination
See comment in PubMed Commons below
Biophys Chem. 2007 Mar;126(1-3):201-8. Epub 2006 Jun 22.

In search of the fusion pore of exocytosis.

Author information

1
Department of Physiology, University of Wisconsin, Wisconsin, USA. mjackson@physiology.wisc.edu

Abstract

Research on calcium-triggered exocytosis has converged on the fusion pore as a critical kinetic intermediate. Using sensitive biophysical methods to record signals from living cells in the act of releasing neurotransmitter or hormone has provided clues about the structure and composition of fusion pores. The dynamics of fusion pore opening, closing, and dilating has revealed how specific proteins transduce a calcium binding signal to catalyze membrane fusion. The fusion pore determines how rapidly neurotransmitter is expelled from a vesicle into the synaptic cleft. This rate places constraints on the form of a synaptic response during different modes of release.

PMID:
16797829
PMCID:
PMC2583116
DOI:
10.1016/j.bpc.2006.05.022
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center