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AAPS J. 2006 May 26;8(2):E353-61.

Modulating inhibitory ligand-gated ion channels.

Author information

1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. cascio@pitt.edu

Abstract

The glycine and gamma-aminobutyric acid receptors (GlyR and GABA(A)R, respectively) are the major inhibitory neurotransmitter-gated receptors in the central nervous system of animals. Given the important role of these receptors in neuronal inhibition, they are prime targets of many therapeutic agents and are the object of intense studies aimed at correlating their structure and function. In this review, the structure and dynamics of these and other homologous members of the nicotinicoid superfamily are described. The modulatory actions of the major biological macromolecules that bind and allosterically affect these receptors are also discussed.

PMID:
16796386
PMCID:
PMC3231573
DOI:
10.1208/aapsj080240
[Indexed for MEDLINE]
Free PMC Article

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