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Bull Math Biol. 2006 Apr;68(3):727-33. Epub 2006 Mar 29.

Why is the number of DNA bases 4?

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1
Department of Mathematics, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. bdeng@math.unl.edu

Abstract

In this paper we construct a mathematical model for DNA replication based on Shannon's mathematical theory for communication. We treat DNA replication as a communication channel. We show that the mean replication rate is maximal with four nucleotide bases under the primary assumption that the pairing time of the G-C bases is between 1.65 and 3 times the pairing time of the A-T bases.

PMID:
16794952
DOI:
10.1007/s11538-005-9019-y
[Indexed for MEDLINE]
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