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Nat Rev Cancer. 2006 Jul;6(7):535-45.

Photodynamic therapy and anti-tumour immunity.

Author information

1
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Abstract

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

PMID:
16794636
PMCID:
PMC2933780
DOI:
10.1038/nrc1894
[Indexed for MEDLINE]
Free PMC Article

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