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Nat Rev Cancer. 2006 Jul;6(7):521-34.

The role of nitric oxide in tumour progression.

Author information

1
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. dai@steele.mgh.harvard.edu

Abstract

Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects. We summarize our current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions. We also discuss potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways.

PMID:
16794635
DOI:
10.1038/nrc1910
[Indexed for MEDLINE]

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