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Nature. 1991 Sep 5;353(6339):43-8.

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.

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Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.


The inhibition of voltage-dependent Ca2+ channels in secretory cells by plasma membrane receptors is mediated by pertussis toxin-sensitive G proteins. Multiple forms of G proteins have been described, differing principally in their alpha subunits, but it has not been possible to establish which G-protein subtype mediates inhibition by a specific receptor. By intranuclear injection of antisense oligonucleotides into rat pituitary GH3 cells, the essential role of the Go-type G proteins in Ca(2+)-channel inhibition is established: the subtypes Go1 and Go2 mediate inhibition through the muscarinic and somatostatin receptors, respectively.

[Indexed for MEDLINE]

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