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J Neurooncol. 2006 Nov;80(2):151-5. Epub 2006 Jun 22.

Expression of SOX9 and SOX10 in central neuroepithelial tumor.

Author information

1
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr 52, Hamburg, 20246, Germany. kordes@uke.uni-hamburg.de

Abstract

The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.

PMID:
16791471
DOI:
10.1007/s11060-006-9180-7
[Indexed for MEDLINE]

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