Abstract
A divergent synthesis of both diastereoisomers of (+/-)-(3-aminocyclopentane)alkylphosphinic acid is described. Both diastereoisomers are obtained in 5 steps from the key (+/-)-(3-hydroxycyclopent-1-ene)alkylphosphinate esters which are prepared via a palladium catalysed C-P bond forming reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Magnetic Resonance Spectroscopy
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Phosphinic Acids / chemical synthesis*
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Phosphinic Acids / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Stereoisomerism
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gamma-Aminobutyric Acid / analogs & derivatives*
Substances
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Phosphinic Acids
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gamma-Aminobutyric Acid