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J Med Chem. 2006 Jun 29;49(13):3763-5.

Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine.

Author information

1
Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Avenida Autopista del Saler, and Instituto de Biomedicina de Valencia, CSIC, E-46010 Valencia, Spain. mjvicent@cipf.es

Abstract

An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA). Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models.

PMID:
16789732
DOI:
10.1021/jm060458x
[Indexed for MEDLINE]

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