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Arch Environ Health. 2004 Dec;59(12):640-9.

Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis.

Author information

1
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599-7435, USA. gammon@unc.edu

Abstract

Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with nondetectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.

PMID:
16789472
PMCID:
PMC4277204
DOI:
10.1080/00039890409602948
[Indexed for MEDLINE]
Free PMC Article

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