Abstract
We have examined the myogenic potential of human embryonic stem (hES) cells in a xeno-transplantation animal model. Here we show that precursors differentiated from hES cells can undergo myogenesis in an adult environment and give rise to a range of cell types in the myogenic lineage. This study provides direct evidences that hES cells can regenerate both muscle and satellite cells in vivo and are another promising cell type for treating muscle degenerative disorders in addition to other myogenic cell types.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biomarkers / metabolism
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Cardiotoxins / metabolism
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Cell Differentiation / physiology
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Cell Line
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Cell Lineage
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Embryonic Stem Cells / cytology
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Embryonic Stem Cells / physiology*
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Humans
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In Situ Hybridization
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Mice
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Mice, Inbred C57BL
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Mice, Inbred NOD
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Mice, SCID
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Muscle Development / physiology*
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Muscle, Skeletal / cytology
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Muscle, Skeletal / growth & development*
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Satellite Cells, Skeletal Muscle / cytology
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Satellite Cells, Skeletal Muscle / physiology*
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Transplantation Conditioning
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Transplantation, Heterologous*