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Semin Cancer Biol. 2007 Jun;17(3):204-13. Epub 2006 May 20.

Evolution of cancer stem cells.

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National Centre for Cell Science, Ganeshkhind, Pune 411007, India.


Cancer as a disease driven by cancer stem cells is a concept that has emerged over the last few years. However, several issues relating to this phenomenon as yet remain unaddressed. A fundamental question is one relating to the identification of events leading to transformation of a normal tissue stem cell to a cancer stem cell. Complete knowledge of this evolutionary process may be crucial for the development of novel effective therapies that influence patient prognosis. The scope of this review is to discuss reports that have begun to elucidate stem cell transformation either as an isolated event or as a progression as an attempt towards understanding some of the critical events involved in the process.

[Indexed for MEDLINE]

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