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Med Chem. 2005 Nov;1(6):591-9.

Quinaldine derivatives: preparation and biological activity.

Author information

1
Zentiva a.s., U kabelovny 130, 102 37 Prague 10, Czech Republic. josef.jampilek@zentiva.cz

Abstract

The series of quinaldine derivatives were prepared, some of them by means of novel synthetic methods. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The prepared compounds were tested for their in vitro antifungal activity as well as for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Structure-activity relationships among the chemical structure, the physical properties and the biological activities of the evaluated compounds are discussed in the article.

PMID:
16787342
[Indexed for MEDLINE]

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