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Biotechnol Lett. 2006 Jun;28(11):837-41. Epub 2006 May 31.

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum.

Author information

1
College of Life Science, South China Normal University, Guangzhou 510631, PR China. liyq9168@hotmail.com

Abstract

Ganoderic acid, from Ganoderma lucidum, at 8 microg/ml inhibited replication of hepatitis B virus (HBV) in HepG2215 cells over 8 days. Production of HBV surface antigen and HBV e antigen were 20 and 44% of controls without ganoderic acid. Male KM mice were significantly protected from liver injury, induced with carbon tetrachloride, by treatment with ganoderic acid at 10 mg and 30 mg/kg x d (by intravenous injection) 7 days. Ganoderic acid at the same dosage also significantly protected the mice from liver injury induced by M. bovis BCG plus lipopolysaccharide (from Escherichia coli 0127:B8).

PMID:
16786250
DOI:
10.1007/s10529-006-9007-9
[Indexed for MEDLINE]

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