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Chem Commun (Camb). 2006 Jul 5;(25):2675-7. Epub 2006 May 23.

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex.

Author information

1
Department of Chemistry & Biochemistry and Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. hao.yan@asu.edu.

Abstract

We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 +/- 0.9 base pairs per turn.

PMID:
16786084
DOI:
10.1039/b603872g
[Indexed for MEDLINE]

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