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Hum Genet. 2006 Sep;120(2):297-300. Epub 2006 Jun 17.

Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.

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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS MSC# 7234, Bethesda, Rockville, MD 20892-7234, USA.


To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.

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