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Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18.

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

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1
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA.

Abstract

Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

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PMID:
16783373
DOI:
10.1038/nsmb1114
[Indexed for MEDLINE]

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