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Cornea. 2006 Jun;25(5):628-30.

Corneal perforation due to severe peripheral ulcerative keratitis in Crohn disease.

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Oxford Eye Hospital, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, United Kingdom.



To describe corneal perforation secondary to severe peripheral ulcerative keratitis (PUK) in a patient with Crohn disease.


Interventional case report.


A 72-year-old male with biopsy-proven Crohn disease presented with reduced vision, PUK, and corneal perforation in the right eye. Despite initial treatment with intravenous methylprednisolone and a conjunctival flap, a tectonic sectorial penetrating keratoplasty was required to preserve the globe and achieve a good visual result.


Crohn disease may be associated with severe PUK leading to corneal perforation. Tectonic corneal grafting combined with treatment of the underlying systemic disease was associated with a favorable outcome.

[Indexed for MEDLINE]

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