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Microbes Infect. 2006 Jul;8(8):2299-304. Epub 2006 Jun 5.

TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae.

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Departamento de Microbiología y Ecología, Facultad de Ciencias Biológicas, Edificio de Investigación, Universitat de València, C/Dr. Moliner 50, 46100 Burjasot, Valencia, Spain.


Toll-like receptors (TLRs) function as sensors for infection that induce the activation of the immune responses. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans. Although both TLR2 and TLR4 have been implicated in the host interaction with C. albicans, their specific role during infection has not been unequivocally established, as conflicting results have been reported. In this review, we summarize and discuss our own and others' key findings about the specific role of TLR2 and TLR4 in murine resistance to candidiasis, and in triggering cytokine secretion by murine cells in response to C. albicans yeasts and hyphae.

[Indexed for MEDLINE]

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