Format

Send to

Choose Destination
Phytomedicine. 2007 Feb;14(2-3):196-203. Epub 2006 Jun 16.

Ginkgo biloba extract protects rat kidney from diabetic and hypoxic damage.

Author information

1
Department of Medicine, Institute of Anatomy, University of Leipzig, Germany.

Abstract

Ginkgo biloba extract EGb 761 was studied for its nephroprotective effects in experimentally diabetic and hypoxic rats. Duration of streptozotocin-induced diabetes was 4 months, that of respiratoric hypoxia of the diabetic group 20 min. The daily dose of 100 mg EGb/kg bodyweight started 1 month after induction of the diabetes. EGb reduced diabetes-induced morphological alterations of the kidney such as increase in volume of glomeruli, capillary tufts, urinary space, and thickening of Bowman's capsule basement membrane. Diabetically increased immunostaining of interstitial collagenes of types I, III, and VI was diminished by the EGb extract. EGb reduced the relative total SOD activity from 163% in diabetic kidney to 46%. Additional hypoxia-induced ultrastructural damage was also diminished.

PMID:
16781853
DOI:
10.1016/j.phymed.2006.03.023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center