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Fitoterapia. 2006 Jul;77(5):339-45. Epub 2006 Apr 30.

Acute and long-term effects of alkaloid extract of Mitragyna speciosa on food and water intake and body weight in rats.

Author information

1
Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand. ekkasit.k@psu.ac.th

Abstract

Acute administration of Mitragyna speciosa (MS) extract (45 and 50 mg/kg) significantly resulted in dose-dependent decreases in food and water intakes (P<0.05) in rats. Prolonged suppressing effects were observed following administration of the MS extract (40 mg/kg) for 60 consecutive days. Moreover, the long-term administration also significantly suppressed weight gaining.

PMID:
16781828
DOI:
10.1016/j.fitote.2006.04.006
[Indexed for MEDLINE]

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